Terrein에 의한 치주인대세포의 항염증 효과
Anti-inflammatory effect of Terrein in periodontal Ligament cells
유미경, 전재규, 지은정, 이호근, 이영희, 이정창, 김태환, 이난희,
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유미경 ( Yu Mi-Kyung ) - 전북대학교 치의학전문대학원 구강보존학교실
전재규 ( Jeon Jae-Gyu ) - 전북대학교 치의학전문대학원 예방치학교실
지은정 ( Jhee Eun-Chung ) - 전북대학교 치과대학 생화학교실
이호근 ( Yi Ho-Keun ) - 전북대학교 치과대학 생화학교실
이영희 ( Lee Young-Hee ) - 전북대학교 치의학전문대학원 생화학교실
이정창 ( Lee Jung-Chang ) - 전북대학교 치의학전문대학원 생화학교실
김태환 ( Kim Tae-Hwan ) - 전북대학교 치의학전문대학원 생화학교실
이난희 ( Lee Nan-Hee ) - 전북대학교 치의학전문대학원 생화학교실
KMID : 0355420090330010001
Abstract
Objective: Terrein was isolated from a microorganism Penicillium species 20135, and Terrein has a anti-oxidant activity and anti-inflammatory activity in human dental pulp cells. However its anti-inflammatory effects are unknown in other types of oral cells. The purpose of this study is to determine the anti-inflammatory effects of Terrein in periodontal ligament cells.
Material and Methods: Human periodontal ligament cells(PDL) obtained from permanent and noncarious teeth were cultured and only third to eighth passages were used. PDL cells were exposed to various concentration of LPS and Terrein. Anti-inflammatory potential of Terrein was checked with expression of MMPs, intercellular adhesion molecule-1(ICAM-1), and vascular cell adhesion molecule-1(VCAM-1).
Results: PDL cells exposed to LPS(1 - 10㎍/㎖) revealed elevated levels of MMP-2, MMP-9, ICAM-1 and VCAM-1. LPS-induced expression of MMP-2, MMP-9, ICAM-1 and VCAM-1 were significantly inhibited by Terrein in a dose and time dependent manner.
Conclusion: These result offers us the possible use of Terrein as an anti-inflammatory agent in periodontitis.
키워드
치주염;치주인대세포;LPS;Terrein
LPS;Terrein;Periodontal Ligament cells;Periodontitis
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